July 14, 2010

MRCP 2 Question 12

Cardiac abnormalities are a known side effect of several cytotoxic drugs.

Which of the following cytotoxic drugs is most likely to lead to fatal ventricular dysrhythmia ?

a) Doxorubicin
b) 5-fluorouracil
c) taxoids
d) cyclopentenyl cytosine
e) trastuzumab

The correct answer is A


Doxorubicin may cause acute effects (within hours) including supraventricular tachyarrhythmias, ECG changes, atrial and ventricular ectopy, and, rarely, fatal ventricular dysrhythmia

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