August 17, 2012

Cytotoxic drugs leading to haemorrhagic cystitis

Nephrotoxicity is a known side effect of several cytotoxic drugs. Which of the following cytotoxic drugs is most likely to lead to haemorrhagic cystitis?

a) Cyclophosphamide
b) 5-fluorouracil
c) Taxoids
d) Cyclopentenyl cytosine
e) Trastuzumab






ANSWER
The correct answer is A


Explanation
Mitomycin has been associated with the haemolytic uraemic syndrome, a syndrome of renal failure and microangiopathic haemolytic anaemia.
Ifosfamide causes haematuria (it is essential to use mesna, a uroprotective agent) and a proximal tubular defect.
Cyclophosphamide may cause haemorrhagic cystitis, hyponatraemia and the syndrome of inappropriate ADH secretion (SIADH).

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