October 20, 2010

USMLE 2 Question 13



Which of the following medications have the highest risk of producing this arrythmia when the patient is also taking amiodarone?

a) Flecainide
b) Phenytoin
c) Propafenone
d) Chloroquine
e) Lidocaine









ANSWER
The correct answer is E



Explanation
Common clinical features in drug-induced torsade de pointes include hypokalemia and cycle-length prolongation just prior to initiation of the arrhythmia.

Among these agents sotalol, which is a class III agent, has the highest risk of producing torsades, which is a polymorphic, pause-dependent ventricular tachycardia causing syncope and sudden cardiac death.

No comments:

Post a Comment

Got something to say? We appreciate your comments: